> [SSRIs causing gut problems] The gut makes 95% of serotonin, which is the main promoter of stress hormones, [[inflammation]], pain, and anxiety. > Serum serotonin fluctuates according to intestinal irritation, but for the average to change very much it's necessary for the liver and [[brain]] to adapt, and that usually takes a few months. Since the [[lungs]] are the main site of serotonin metabolism, an air ionizer near your bed can help. > B6 helps for turning tryptophan into niacin rather than serotonin. > Yes, it allows a positive kind of mental energy, since high serotonin causes conservative, defensive authoritarian avoidance [Lower serotonin leading to holism]. > Effective mental effort is easier to make when serotonin isn't excessive; attitude and chemistry interact, both directions. > Some people who haven't had ideal results from bromocriptine have had better results from tianeptine, and/or lisuride, and/or [[cyproheptadine]] [anti-serotonin drugs]. > [[Cyproheptadine]] might be helpful for reducing sensitivity to intestinal irritants. > [Can anti-serotonin drugs permanently fix a problem, even if taken only for a short while?] Yes, but it's important to keep adjusting [[thyroid]] and [[progesterone]] according to temperature, [[pulse]], etc. > [[thyroid]] is the best thing for controlling serotonin's effects. The drugs that act on "[[receptors]]" act simultaneously on many things; one effect of some of them is a selective "agonist" effect on the "receptor" which is involved in negative feedback, turning off the cells that produce serotonin. Wikipedia is a function of consensus; according to them, serotonin is a happy hormone, and there are no conspiracies of government officials and bankers. > [High serotonin] It's important to know how it was measured, and what your platelet count was. Is your intestine inflamed? Since serotonin affects bone metabolism, have your serum [[calcium]], phosphate, parathyroid hormone, vitamin D3, [[prolactin]], and cortisol been measured? > I don't think doctors know what to do for regulating serotonin. Vitamin B6 helps to direct tryptophan toward niacinamide, away from serotonin. [[Gelatin]] contains no tryptophan, so things like consomme can be helpful. Raw carrots, because of their antiseptic effect, help to lower irritation and bloating. [[Antibiotics]] can be helpful, when the small intestine is overgrown with bacteria. [[thyroid]] supplementation will lower cholesterol. Some people get very sleepy with just two milligrams of Periactin, so I think it's good to start with one mg. the first night. Two milligrams can make a big difference, and when symptoms stop the effects can last for days without using it. < See also [#Anti-Serotonin Drugs](https://archive.ph/OJZkW#Anti-Serotonin_Drugs). >