> [What would you recommend for someone experiencing septic shock?] [[Sugar]], [[aspirin]], naloxone or naltrexone, [[antibiotics]] and laxatives. [Source](https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-229039) > [!summary]- This exchange included references to studies showing beneficial effects of [[aspirin]] in [[inflammation]], sepsis, and neuroprotection. Click to expand. > > > [!note] Fletcher JR, Herman CM, Ramwell PW. *Improved survival in endotoxemia with [[aspirin]] and indomethacin pretreatment. Surg Forum. 1976;27(62):11–12.* > > > [!info] Pretreatment with [[aspirin]] and indomethacin improved survival in endotoxemic conditions. > > > [!note] Schimmel D, Schimmel I, Lutter K, Putsche R. *[Effect of acetylsalicylic acid on experimentally induced endotoxin reactions in swine]. Arch Exp Veterinarmed. 1976;30(6):951–957.* > > > [!info] Pretreatment with acetylsalicylic acid and indomethacin may delay or moderate clinical symptoms likely triggered by endotoxin. [Article in German] > > > [!note] Sossdorf M, Otto GP, Boettel J, Winning J, Lösche W. *Benefit of low-dose [[aspirin]] and non-steroidal anti-inflammatory drugs in septic patients. Crit Care. 2013 Jan 8;17(1):402.* > > > [!info] Low-dose [[aspirin]] or NSAIDs were associated with decreased hospital mortality in patients with severe sepsis or septic shock. > > > [!note] Ghosh A, Dhumal VR, Tilak AV, Das N, Singh A, Bondekar AA. *Evaluation of nootropic and neuroprotective effects of low dose [[aspirin]] in rats. J Pharmacol Pharmacother. 2011 Jan;2(1):3–6.* > > > [!info] [[Aspirin]] improved [[memory]] retention and reduced [[serotonin]]-related behavioral effects in rats exposed to electroconvulsive shock, suggesting a neuroprotective and nootropic effect via serotonergic [[inhibition]]. > > > [!note] Sanchez MA, Thomas CB, O'Neal HR. *Do [[aspirin]] and statins prevent severe sepsis? Curr Opin Infect Dis. 2012 Jun;25(3):345–350.* > > > [!info] Observational data and animal models suggest [[aspirin]] and statins may reduce the incidence and severity of sepsis by modulating [[inflammation]] and platelet activity. ---