> Bihari thinks naltrexone works by increasing endorphins, I think excess endorphins are often the problem, and the antagonist can sometimes be helpful. The endorphins differ in their effects on the two sides of the body, so when I knew two women (within the same year) who had been having mysterious one-sided symptoms for a few months before discovering that they had ovarian [[cancer]] (on the same side), I thought that the endorphins were probably involved, maybe to suppress pain on that side. Naloxone and naltrexone have some effects that aren't directly related to the endorphins, on estrogen and histamine. > I have seen good results from using naloxone for 3 or 4 days; naltrexone has similar effects. Doses of one milligram or less can sometimes be effective. I don’t consider pramipexole to be safe. Ginkgo is fairly safe. > [LDN treatment] I think it's safe to take 5 or 10 mg of naltrexone daily for a few days, but I don't think it should be used continuously; I have known people who had good results, repeating the short courses two or three times in a year. > Estrogen can cause ovarian cysts to develop, and can contribute to the development of [[skin]] tags and [[moles]]. Its effects on the urethra might help with incontinence, but it can cause problems with the bladder muscle, and cystitis.