> [TOPICAL USE] It would be hard to regulate the dose via the [[skin]]. > It's good to start with about half a milligram, at bedtime, to judge its effects when sedation isn't risky. > Cyproheptadine, 2 to 4 mg at bedtime, would help with his [[sleep]] as well as the [[cancer]]. It also has [[calcium]] blocking action, aldosterone antagonism, and antagonizes [[serotonin]]'s antidiuretic effect. > _[Jared: Dr. Peat, As a woman, I'm trying to figure out if nortriptyline (taken for IBS at 10 mg/day) could be exacerbating the IBS since it is most likely increasing serotonin. Would that be true? After having [[surgery]] to remove breast implants, I have had terrible neuropathy. Could that be serotonin and endotoxin related? What would be the most effective steps to heal the neuropathy? Thank you for your work. Warmly,]_ > > Surgical stress can result in prolonged hormonal imbalance, including low [[thyroid]] and high estrogen and serotonin. Have you had [[blood tests]] for [[thyroid]] and vitamin D, etc.? Have you tried cyproheptadine for the IBS? > > Expert Rev Gastroenterol Hepatol. 2010 Jun; 4(3): 293–304. Management of functional abdominal pain and irritable bowel syndrome in children and adolescents Eric Chiou1 and  Samuel Nurko.  …………………….. > Cyproheptadine > Cyproheptadine is a medication with multiple mechanisms, including antihistaminic, anticholinergic and antiserotonergic properties, as well as possible calcium channel blockade effects. It has been used in appetite stimulation and prevention of pain and vomiting in abdominal migraine and cyclic vomiting syndrome. Sadeghian et al. studied the use of cyproheptadine in 29 children and adolescents (aged 4.5–12 years) diagnosed with FAP in a 2-week, double-blind placebo-controlled trial. At the end of the study, 86% in the cyproheptadine group had improvement or resolution of abdominal pain compared with 35.7% in the placebo group (p = 0.003) [56]. These results need to be confirmed with additional larger trials. (Submitted by [@JaredVerax](https://x.com/JaredVerax)) [Message date: _March 2021_, Submitted: _Jan 2025_] > [Antihistamine recommendations] Have you tried other types of antihistamine, such as ketotifen, diphenhydramine, or cyproheptadine? [Source](https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-242902)