> Cannabis is antiandrogenic or estrogenic, but it can be protective in some situations. > [CBD] It can probably be helpful for lowering nitric oxide in some situations, but there’s some evidence that it increases prostaglandins, which could be harmful in a person whose tissues have a lot of [[PUFA]]. The acidic form, CBDA, seems likely to be more broadly protective. [(Reference)](https://archive.ph/o/OJZkW/https://raypeatforum.com/community/threads/ray-peat-email-advice-depository.1035/page-12%23post-141957)