> Caffeine increases your metabolic rate, so it's important to take it with food, including enough [[sugar]]. Coffee and cocoa are very good [[magnesium]] sources. Cocoa contains both bromocriptine and caffeine, bromocriptine seems to be more stimulating to the [[heart]] than to the [[brain]]. > [Do you think it is safe to use caffeine tablet of 600 mg or more to treat fatty liver?] That would be too much caffeine at once, unless it's with a big meal to slow its absorption. > [Caffeine and Estrogens?] [Peat was sent the abstract of a [[study]] that showed that estradiol is increased by 70% in women consuming >=500 mg caffeine daily. Replying to that mail he sent abstracts of several studies. [See post.](https://archive.ph/o/OJZkW/https://raypeatforum.com/community/threads/ray-peat-email-advice-depository.1035/page-5%23post-24334)] > [Here's a study that says 3 mg/kg caffeine is ergogenic, while 6 mg/kg elevates epinephrine. Considering its half-life, doses above around 600 mg/day will tend to raise epinephrine in most people, so do you think this is a good cutoff whereat [[thyroid]] (T3 and T4) supplementation should begin to raise temps and pulse in the place of larger amounts of caffeine (for example 800 - 1600 mg)?] As long as it isn’t increasing free fatty acids and glycerol I think it’s safe, and I suspect that there might be beneficial effects other than ergogenic at the higher doses. Unless a person is in the habit of regularly running to exhaustion, that kind of study isn’t very useful. [Source](https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-208989)