> [Do high level of Thyroglobulin Antibodies and [[thyroid]] Peroxidase (TPO) Antibodies show autoimmune thyroditis?] When TSH is too high for a long time, it causes [[inflammation]] in the gland, and the antibodies are in reaction to that > [Type 1 diabetic with TPO antibodies] Was your TSH tested? Usually the antibodies just mean that the [[thyroid]] gland is inflamed, and increased TSH can be responsible for that. T4 can suppress TSH protectively, but since intracellular glucose is needed for making T3, [[diabetes]] can interfere with that. I think some T3 is always appropriate with [[diabetes]]. [TSH was 3.9] I think the high TSH explains the antibodies, and a combination of T4 and T3 is usually all that’s needed; it usually takes a few months after suppressing TSH for the antibodies to decrease. Cortisol would be important to know, also estrogen and [[prolactin]] would be more informative than the common [[thyroid]] tests. > [Autoimmune diets] Have you seen my website article on [[milk]]? It mentions some of the things behind [[gluten]] sensitivity. [[Hypothyroidism]] is one thing that commonly causes leaky gut, as well as leaky liver, muscles, [[heart]], [[thyroid]] gland, etc. The immune system reacts to the leakiness, and although it might be an effect, rather than a cause, the presence of antibodies is sometimes said to show autoimmunity. > [Test for cross-reactive foods] The presence of specific antibodies means that someone has been exposed to an antigen, but it doesn't indicate that they will react badly to it. [(Reference)](https://archive.ph/o/OJZkW/https://raypeatforum.com/community/threads/ray-peat-email-advice-depository.1035/page-9%23post-119416)