> I don't know anyone who has a **stomach reaction** when they dissolve the aspirin in hot water, and then take it with food. There are alternatives, such as [[magnesium]] salsalate* or just plain salicylic acid (which should be used dissolved and with food). People using it with [[cancer]] usually take a daily total of 6 grams or more. [[Vitamin K]] protects against bleeding and other effects of prolonged aspirin use. \*[Possible typo for magnesium salicylate?] > I mostly use the pure crystals, but in Mexico I use the Bayer tablets. > If the aspirin smells like vinegar it's decomposing, otherwise the expiration date doesn't matter. I have some aspirin, USP, that's at least 10 years old that's still good. > **[Starch in aspirin tablets problematic?]** Only if it causes symptoms such as hemorrhoids, asthma, or headaches. > **[Safety of animal aspirin]** They sell aspirin, USP, for animals, which is the same as used for people, except that it doesn't contain the toxic additives of the tablets. > **[Use of Aspirin in bath]** Some therapists have advocated it. > People sometimes take that much aspirin attempting suicide, but I don't think that's relevant to a conclusion about antinociception. > It depends on the context; aspirin makes you need more [[vitamin K]], even when you aren't using much. People who use aspirin for arthritis or [[cancer]] often take several grams a day. > 7000 mg is a lot, and it's very important to take [[vitamin K]] with aspirin. > When aspirin and niacinamide lower the temperature I think it's because they lower the stress hormones. > I think a little aspirin, regularly if not daily, is good prevention [CANCER], if you are sure to get enough [[vitamin K]], to prevent excess bleeding. The amount depends on how you react to it, and can change as your metabolism adjusts. Taking some at bedtime can be very helpful for sleeping; sometimes I take about 500 mg at night, but other times just a little. I think the crystals are more stable, but I keep the big container (a multi-year supply) in the freezer, and keep out enough for a couple of months. The powdered forms developed an acetic acid smell with time, the crystals don't. > USP aspirin from any source is usually good. I buy it by the kilo. > **[Aspirin allergy]** I know people who had lifelong "aspirin allergy" who now use it regularly. I think part of it is the metabolic problems caused by [[PUFA]] and low [[thyroid]] function. > **[Safe upper limit?]** It depends on the context; aspirin makes you need more [[vitamin K]], even when you aren't using much. People who use aspirin for arthritis or [[cancer]] often take several grams a day. > **[Right dosage of aspirin for use as anticoagulant?]** Clotting time must be measured when taking any anticoagulant. > **[Aspirin prior to [[surgery]]? (testicular [[cancer]])]** If [[vitamin K]] is used generously, aspirin wouldn’t be likely to cause a bleeding problem. [[Progesterone]] could be used to lower luteinizing hormone before [[surgery]], if that’s high. I think tetracycline (or a derivative) would be helpful to use with the aspirin. It’s important to check [[thyroid]] function and [[vitamin D]]. > **[Aspirin smells like vinegar. Is it safe?]** It breaks down into salicylic acid and acetic acid, and both of those are safe.