> [Cyproheptadine] I think [[cyproheptadine]] is a safe antiserotonin drug [serotonin syndrome]. > [Mirtazapine] I think its antiserotonin effects might be helpful, but I haven’t tried it myself. > [Tianeptine] I have known a few people who had very good results with tianeptine, and a couple who got side effects from it. I think any of the antiserotonin drugs will eventually cause side effects, and should only be used until a problem is corrected, for example when an enlarged pituitary is normalized. I think the same effects can be produced with nutrition and hormones, without the possible problems. > [Can anti-[[serotonin]] drugs permanently fix a problem, even if taken only for a short while?] Yes, but it's important to keep adjusting [[thyroid]] and [[progesterone]] according to temperature, [[pulse]], etc. > [[Thyroid]] is the best thing for controlling [[serotonin]]'s effects. The drugs that act on "[[receptors]]" act simultaneously on many things; one effect of some of them is a selective "agonist" effect on the "receptor" which is involved in negative feedback, turning off the cells that produce [[serotonin]]. Wikipedia is a function of consensus; according to them, [[serotonin]] is a happy hormone, and there are no conspiracies of government officials and bankers. > [Ritanserin] I haven’t had any experience with ritanserin, don’t recommend it, and don’t recall discussing it. [Forum Discussion: Safety of Antiseronin Drugs](https://archive.ph/o/OJZkW/https://raypeatforum.com/community/threads/rp-email-advice-discussion-safety-of-antiserotonin-drugs.13800/) > [I know you think that anti-serotonin drugs eventually cause problems, but you've said that amitryptyline is relatively safe. Do you think it's safer than mirtazapine for moderate-term use? I've read that mirtazapine's a "successor" to mianserin.] Although the structure suggests that it might be safer, fibrosis has been associated with both of them, and I think it’s best to concentrate on optimizing the metabolism, with [[thyroid]], pregnenolone, progesterone, etc. [Source](https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-214214)